[HTML][HTML] In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor γ response element in the mouse pdx-1 promoter
We reported that peroxisome proliferator-activated receptor γ (PPARγ) transcriptionally
regulates the β-cell differentiation factor pancreatic duodenal homeobox (PDX)-1 based on
in vitro RNA interference studies. We have now studied mice depleted of PPARγ within the
pancreas (PANC PPARγ-/-) created by a Cre/loxP recombinase system, with Cre driven by
the pdx-1 promoter. Male PANC PPARγ-/-mice were hyperglycemic at 8 weeks of age
(8.1±0.2 mm versus 6.4±0.3 mm, p= 0.009) with islet cytoarchitecture and pancreatic mass of …
regulates the β-cell differentiation factor pancreatic duodenal homeobox (PDX)-1 based on
in vitro RNA interference studies. We have now studied mice depleted of PPARγ within the
pancreas (PANC PPARγ-/-) created by a Cre/loxP recombinase system, with Cre driven by
the pdx-1 promoter. Male PANC PPARγ-/-mice were hyperglycemic at 8 weeks of age
(8.1±0.2 mm versus 6.4±0.3 mm, p= 0.009) with islet cytoarchitecture and pancreatic mass of …