[PDF][PDF] Thymic lymphomas in interleukin 9 transgenic mice
JC Renauld, N Van der Lugt, A Vink, M Van Roon… - Oncogene, 1994 - researchgate.net
Transgenic mice overexpressing the interleukin 9 gene were generated to study the
biological activity of this cytokine in vivo. Although no major histological or morphological
modifications of the lymphoid system were observed in most animals,-7% of transgenic mice
developed thymic lymphomas at the age of 3–9 months. The tumor cells, which were clonal,
with unique T cell rearrangements, were double positive for the expression of CD4 and CD8.
The need for additional transforming events, suggested by the low incidence of spontaneous …
biological activity of this cytokine in vivo. Although no major histological or morphological
modifications of the lymphoid system were observed in most animals,-7% of transgenic mice
developed thymic lymphomas at the age of 3–9 months. The tumor cells, which were clonal,
with unique T cell rearrangements, were double positive for the expression of CD4 and CD8.
The need for additional transforming events, suggested by the low incidence of spontaneous …