Genetic variation of DKK3 may modify renal disease severity in ADPKD
Significant variation in the course of autosomal dominant polycystic kidney disease
(ADPKD) within families suggests the presence of effect modifiers. Recent studies of the
variation within families harboring PKD1 mutations indicate that genetic background may
account for 32 to 42% of the variance in estimated GFR (eGFR) before ESRD and 43 to 78%
of the variance in age at ESRD onset, but the genetic modifiers are unknown. Here, we
conducted a high-throughput single-nucleotide polymorphism (SNP) genotyping association …
(ADPKD) within families suggests the presence of effect modifiers. Recent studies of the
variation within families harboring PKD1 mutations indicate that genetic background may
account for 32 to 42% of the variance in estimated GFR (eGFR) before ESRD and 43 to 78%
of the variance in age at ESRD onset, but the genetic modifiers are unknown. Here, we
conducted a high-throughput single-nucleotide polymorphism (SNP) genotyping association …