Mouse models of polycystic kidney disease
PD Wilson - Current topics in developmental biology, 2008 - Elsevier
Polycystic kidney disease (PKD) is a diverse group of human monogenic lethal conditions
inherited as autosomal dominant (AD) or recessive (AR) traits. Recent development of
genetically engineered mouse models of ADPKD, ARPKD, and nephronophthisis/medullary
cystic disease (NPHP) are providing additional insights into the molecular mechanisms
governing of these disease processes as well as the developmental differentiation of the
normal kidney. Genotypic and phenotypic mouse models are discussed and provide …
inherited as autosomal dominant (AD) or recessive (AR) traits. Recent development of
genetically engineered mouse models of ADPKD, ARPKD, and nephronophthisis/medullary
cystic disease (NPHP) are providing additional insights into the molecular mechanisms
governing of these disease processes as well as the developmental differentiation of the
normal kidney. Genotypic and phenotypic mouse models are discussed and provide …