[HTML][HTML] Electron cryomicroscopy structure of a membrane-anchored mitochondrial AAA protease
FtsH-related AAA proteases are conserved membrane-anchored, ATP-dependent molecular
machines, which mediate the processing and turnover of soluble and membrane-embedded
proteins in eubacteria, mitochondria, and chloroplasts. Homo-and hetero-oligomeric
proteolytic complexes exist, which are composed of homologous subunits harboring an
ATPase domain of the AAA family and an H41 metallopeptidase domain. Mutations in
subunits of mitochondrial m-AAA proteases have been associated with different …
machines, which mediate the processing and turnover of soluble and membrane-embedded
proteins in eubacteria, mitochondria, and chloroplasts. Homo-and hetero-oligomeric
proteolytic complexes exist, which are composed of homologous subunits harboring an
ATPase domain of the AAA family and an H41 metallopeptidase domain. Mutations in
subunits of mitochondrial m-AAA proteases have been associated with different …