[HTML][HTML] The C5 domain of the collagen VI α3 (VI) chain is critical for extracellular microfibril formation and is present in the extracellular matrix of cultured cells
SR Lamandé, M Mörgelin, NE Adams, C Selan… - Journal of Biological …, 2006 - ASBMB
Collagen VI, a microfibrillar protein found in virtually all connective tissues, is composed of
three distinct subunits, α1 (VI), α2 (VI), and α3 (VI), which associate intracellularly to form
triple helical heterotrimeric monomers then dimers and tetramers. The secreted tetramers
associate end-to-end to form beaded microfibrils. Although the basic steps in assembly and
the structure of the tetramers and microfibrils are well defined, details of the interacting
protein domains involved in assembly are still poorly understood. To explore the role of the …
three distinct subunits, α1 (VI), α2 (VI), and α3 (VI), which associate intracellularly to form
triple helical heterotrimeric monomers then dimers and tetramers. The secreted tetramers
associate end-to-end to form beaded microfibrils. Although the basic steps in assembly and
the structure of the tetramers and microfibrils are well defined, details of the interacting
protein domains involved in assembly are still poorly understood. To explore the role of the …