[PDF][PDF] Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-α
K Sriram, JM Matheson, SA Benkovic, DB Miller… - 2006 - digitalcommons.unl.edu
Enhanced expression of tumor necrosis factor (TNF)-, is associated with the
neuropathological effects underlying disease-, trauma-and chemically induced
neurodegeneration. Previously, we have shown that deficiency of TNF receptors protects
against MPTP-induced striatal dopaminergic neurotoxicity, findings suggestive of a role for
TNF-in neurodegeneration. Here, we demonstrate that deficiency of TNF receptors
suppresses microglial activation and alters the susceptibility of brain regions to MPTP. MPTP …
neuropathological effects underlying disease-, trauma-and chemically induced
neurodegeneration. Previously, we have shown that deficiency of TNF receptors protects
against MPTP-induced striatal dopaminergic neurotoxicity, findings suggestive of a role for
TNF-in neurodegeneration. Here, we demonstrate that deficiency of TNF receptors
suppresses microglial activation and alters the susceptibility of brain regions to MPTP. MPTP …