Microglial reaction in MPTP (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine) induced Parkinson's disease mice model

A Członkowska, M Kohutnicka… - …, 1996 - Elsevier
We studied the microglial reaction in mice using the 1-methyl-4-phenyl-1, 2, 3, 6-
tetrahydropyridine (MPTP)-induced model for Parkinson's disease (PD). Microglial cells
were identified by means of the Griffonia simplicifolia lectin (GSA-I-B4). Dopaminergic
neurons were marked by tyrosine hydroxylase antibodies. Microglial activation was
demonstrated by an increase in cellular number and changes of morphology (increased
lectin staining, larger cell bodies and thicker processes) were seen in the substantia nigra …