Atherosclerosis is a chronic inflammatory disease that is characterized by the development
of fibrotic plaques in the arterial wall. The disease exhibits a complex aetiology and its
progression is influenced by a number of environmental and genetic risk factors. The
cytokine interferon-γ (IFN-γ), a key regulator of immune function, is highly expressed in
atherosclerotic lesions and has emerged as a significant factor in atherogenesis. Evidence
from both mouse models of atherosclerosis and in vitro cell culture has suggested that the …