Antagonizing L-type Ca2+ channel reduces development of abnormal involuntary movement in the rat model of L-3, 4-dihydroxyphenylalanine-induced dyskinesia
S Schuster, E Doudnikoff, D Rylander, A Berthet… - Biological …, 2009 - Elsevier
BACKGROUND: Chronic L-3, 4-dihydroxyphenylalanine (L-DOPA) treatment of Parkinson's
disease (PD) leads to debilitating involuntary movements, termed L-DOPA-induced
dyskinesia. Striatofugal medium spiny neurons (MSN) lose their dendritic spines and cortico-
striatal glutamatergic synapses in PD and in experimental models of DA depletion. This loss
of connectivity is triggered by a dysregulation of intraspine Cav1. 3 L-type Ca2+ channels.
Here we address the possible implication of DA denervation-induced spine pruning in the …
disease (PD) leads to debilitating involuntary movements, termed L-DOPA-induced
dyskinesia. Striatofugal medium spiny neurons (MSN) lose their dendritic spines and cortico-
striatal glutamatergic synapses in PD and in experimental models of DA depletion. This loss
of connectivity is triggered by a dysregulation of intraspine Cav1. 3 L-type Ca2+ channels.
Here we address the possible implication of DA denervation-induced spine pruning in the …