[HTML][HTML] The efficient catabolism of thrombin-protease nexin 1 complexes is a synergistic mechanism that requires both the LDL receptor-related protein and cell …
MF Knauer, SJ Kridel, SB Hawley, DJ Knauer - Journal of Biological …, 1997 - ASBMB
Protease nexin 1 (PN1) is a serine protease inhibitor (SERPIN) that acts as a suicide
substrate for thrombin (Th) and urokinase-type plasminogen activator (uPA). PN1 forms 1: 1
stoichiometric complexes with these proteases, which are then rapidly bound, internalized,
and degraded. The low density lipoprotein receptor-related protein (LRP) is the receptor
responsible for the internalization of protease-PN1 complexes. However, we found that the
LRP is not significantly involved in the initial cell surface binding of thrombin-PN1, leading …
substrate for thrombin (Th) and urokinase-type plasminogen activator (uPA). PN1 forms 1: 1
stoichiometric complexes with these proteases, which are then rapidly bound, internalized,
and degraded. The low density lipoprotein receptor-related protein (LRP) is the receptor
responsible for the internalization of protease-PN1 complexes. However, we found that the
LRP is not significantly involved in the initial cell surface binding of thrombin-PN1, leading …