[HTML][HTML] Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver
AM Hall, K Kou, Z Chen, TA Pietka, M Kumar… - Journal of lipid …, 2012 - ASBMB
Intrahepatic lipid accumulation is extremely common in obese subjects and is associated
with the development of insulin resistance and diabetes. Hepatic diacylglycerol and
triacylglycerol synthesis predominantly occurs through acylation of glycerol-3-phosphate.
However, an alternative pathway for synthesizing diacylglycerol from monoacylglycerol
acyltransferases (MGAT) could also contribute to hepatic glyceride pools. MGAT activity and
the expression of the three genes encoding MGAT enzymes (MOGAT1, MOGAT2, and …
with the development of insulin resistance and diabetes. Hepatic diacylglycerol and
triacylglycerol synthesis predominantly occurs through acylation of glycerol-3-phosphate.
However, an alternative pathway for synthesizing diacylglycerol from monoacylglycerol
acyltransferases (MGAT) could also contribute to hepatic glyceride pools. MGAT activity and
the expression of the three genes encoding MGAT enzymes (MOGAT1, MOGAT2, and …