[HTML][HTML] Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome [S]
MK Basantani, MT Sitnick, L Cai, DS Brenner… - Journal of lipid …, 2011 - ASBMB
PNPLA3 (adiponutrin, calcium-independent phospholipase A 2 epsilon [iPLA 2∊]) is an
adipose-enriched, nutritionally regulated protein that belongs to the patatin-like
phospholipase domain containing (PNPLA) family of lipid metabolizing proteins. Genetic
variations in the human PNPLA3 gene (ie, the rs738409 I148M allele) has been strongly
and repeatedly associated with fatty liver disease. Although human PNPLA3 has
triacylglycerol (TAG) hydrolase and transacylase activities in vitro, its in vivo function and …
adipose-enriched, nutritionally regulated protein that belongs to the patatin-like
phospholipase domain containing (PNPLA) family of lipid metabolizing proteins. Genetic
variations in the human PNPLA3 gene (ie, the rs738409 I148M allele) has been strongly
and repeatedly associated with fatty liver disease. Although human PNPLA3 has
triacylglycerol (TAG) hydrolase and transacylase activities in vitro, its in vivo function and …