[HTML][HTML] Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes
LC Silva, OB David, Y Pewzner-Jung, EL Laviad… - Journal of lipid …, 2012 - ASBMB
Little is known about the effects of altering sphingolipid (SL) acyl chain structure and
composition on the biophysical properties of biological membranes. We explored the
biophysical consequences of depleting very long acyl chain (VLC) SLs in membranes
prepared from lipid fractions isolated from a ceramide synthase 2 (CerS2)-null mouse, which
is unable to synthesize C22–C24 ceramides. We demonstrate that ablation of CerS2 has
different effects on liver and brain, causing a significant alteration in the fluidity of the …
composition on the biophysical properties of biological membranes. We explored the
biophysical consequences of depleting very long acyl chain (VLC) SLs in membranes
prepared from lipid fractions isolated from a ceramide synthase 2 (CerS2)-null mouse, which
is unable to synthesize C22–C24 ceramides. We demonstrate that ablation of CerS2 has
different effects on liver and brain, causing a significant alteration in the fluidity of the …