[HTML][HTML] Differential regulation of dihydroceramide desaturase by palmitate versus monounsaturated fatty acids: implications for insulin resistance
W Hu, J Ross, T Geng, SE Brice, LA Cowart - Journal of Biological …, 2011 - ASBMB
Much data implicate saturated fatty acids in deleterious processes associated with obesity,
diabetes, and the metabolic syndrome. Many of these changes may be due to aberrant
generation of bioactive lipids when saturated fatty acid availability to tissues is increased. On
the other hand, studies are emerging that implicate the monounsaturated fatty acid oleate in
protection from saturated fat mediated toxicity; however, the mechanisms are not well
understood. Our data demonstrate a novel role for palmitate in increasing mRNA encoding …
diabetes, and the metabolic syndrome. Many of these changes may be due to aberrant
generation of bioactive lipids when saturated fatty acid availability to tissues is increased. On
the other hand, studies are emerging that implicate the monounsaturated fatty acid oleate in
protection from saturated fat mediated toxicity; however, the mechanisms are not well
understood. Our data demonstrate a novel role for palmitate in increasing mRNA encoding …