[HTML][HTML] Expression of stem cell factor and its receptor c-Kit during the development of intrahepatic cholangiocarcinoma
T Mansuroglu, P Ramadori, J Dudás, I Malik… - Laboratory …, 2009 - Elsevier
Stem cell factor (SCF) and its receptor, c-Kit, constitute an important signal transduction
system with proliferative and anti-apoptotic functions. Besides regulating hemopoietic stem
cell proliferation and liver regeneration, it has been implicated in the regulation of human
malignancies. However, the cellular expression of the SCF–c-Kit gene system in the liver
during cholangiocarcinogenesis has not been studied to date. The protein-and mRNA-
expression levels of SCF and c-Kit genes were examined in normal rat liver, in isolated …
system with proliferative and anti-apoptotic functions. Besides regulating hemopoietic stem
cell proliferation and liver regeneration, it has been implicated in the regulation of human
malignancies. However, the cellular expression of the SCF–c-Kit gene system in the liver
during cholangiocarcinogenesis has not been studied to date. The protein-and mRNA-
expression levels of SCF and c-Kit genes were examined in normal rat liver, in isolated …