Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway
IV Rosado, F Langevin, GP Crossan… - Nature structural & …, 2011 - nature.com
Nature structural & molecular biology, 2011•nature.com
Metabolism is predicted to generate formaldehyde, a toxic, simple, reactive aldehyde that
can damage DNA. Here we report a synthetic lethal interaction in avian cells between
ADH5, encoding the main formaldehyde-detoxifying enzyme, and the Fanconi anemia (FA)
DNA-repair pathway. These results define a fundamental role for the combined action of
formaldehyde catabolism and DNA cross-link repair in vertebrate cell survival.
can damage DNA. Here we report a synthetic lethal interaction in avian cells between
ADH5, encoding the main formaldehyde-detoxifying enzyme, and the Fanconi anemia (FA)
DNA-repair pathway. These results define a fundamental role for the combined action of
formaldehyde catabolism and DNA cross-link repair in vertebrate cell survival.
Abstract
Metabolism is predicted to generate formaldehyde, a toxic, simple, reactive aldehyde that can damage DNA. Here we report a synthetic lethal interaction in avian cells between ADH5, encoding the main formaldehyde-detoxifying enzyme, and the Fanconi anemia (FA) DNA-repair pathway. These results define a fundamental role for the combined action of formaldehyde catabolism and DNA cross-link repair in vertebrate cell survival.
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