Prolonged survival of pig orthotopic heart grafts treated with cyclosporin A
RY Calne, DJG White, K Rolles, DP Smith… - The Lancet, 1978 - Elsevier
RY Calne, DJG White, K Rolles, DP Smith, BM Herbertson
The Lancet, 1978•ElsevierCyclosporin A was given to pigs receiving orthotopic cardiac allografts from donors
mismatched at the major locus. Median survival in 20 control pigs was only 6 days; in 5 pigs
given cyclosporin A at 15 mg/kg on 3 days median survival was 22 days; and when 6
animals were given 25 mg/kg intra-muscularly for 2 days and then orally median survival is>
68 days, with 4 animals still alive.
mismatched at the major locus. Median survival in 20 control pigs was only 6 days; in 5 pigs
given cyclosporin A at 15 mg/kg on 3 days median survival was 22 days; and when 6
animals were given 25 mg/kg intra-muscularly for 2 days and then orally median survival is>
68 days, with 4 animals still alive.
Abstract
Cyclosporin A was given to pigs receiving orthotopic cardiac allografts from donors mismatched at the major locus. Median survival in 20 control pigs was only 6 days; in 5 pigs given cyclosporin A at 15 mg/kg on 3 days median survival was 22 days; and when 6 animals were given 25 mg/kg intra- muscularly for 2 days and then orally median survival is >68 days, with 4 animals still alive.
Elsevier