[HTML][HTML] Homotransplantation of the liver in humans
TE STARZL, TL Marchioro, KN Von Kaulla… - Surgery, gynecology …, 1963 - ncbi.nlm.nih.gov
TE STARZL, TL Marchioro, KN Von Kaulla, G Hermann, RS Brittain, WR Waddell
Surgery, gynecology & obstetrics, 1963•ncbi.nlm.nih.govAN IDEAL TREATMENT for several kinds of liver disease would be removal of the diseased
organ and orthotopic replacement with a hepatic homograft. Patients with primary carcinoma
of the liver, congenital atresia of the bile ducts, and terminal cirrhosis would all be
candidates. The application of such therapy depends, first, upon the employment of a
satisfactory operative procedure and, second, upon the use of suitable measures to prevent
the immunologic rejection of the graft. Recently, solutions to these problems have evolved …
organ and orthotopic replacement with a hepatic homograft. Patients with primary carcinoma
of the liver, congenital atresia of the bile ducts, and terminal cirrhosis would all be
candidates. The application of such therapy depends, first, upon the employment of a
satisfactory operative procedure and, second, upon the use of suitable measures to prevent
the immunologic rejection of the graft. Recently, solutions to these problems have evolved …
AN IDEAL TREATMENT for several kinds of liver disease would be removal of the diseased organ and orthotopic replacement with a hepatic homograft. Patients with primary carcinoma of the liver, congenital atresia of the bile ducts, and terminal cirrhosis would all be candidates. The application of such therapy depends, first, upon the employment of a satisfactory operative procedure and, second, upon the use of suitable measures to prevent the immunologic rejection of the graft.
Recently, solutions to these problems have evolved which are at least partially satisfactory. The technical requirements for successful canine hepatic transplantation were defined (9). In addition, a regimen of anti-rejection therapy was developed in patients receiving renal homografts which resulted in consistent prolonged survival of the foreign tissue (11, 12).
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