In vitro evidence of involvement of the epithelial y+ transporter in β-defensin production on the ocular surface
K Jäger, A Nielitz, F Garreis, S Sel, H Nave… - Annals of Anatomy …, 2011 - Elsevier
To analyse the hypothesis as to whether there is a functional relationship between human
cationic amino acid transporters (hCATs, y+ transporter, the main transporter of l-arginine
and l-lysine) and human β-defensin (important components of immune function) production
on the ocular surface, arginase and nitrate monoxide synthase (NOS), enzymes that
compete for l-arginine, were inhibited by norNOHA (N (omega)-hydroxy-nor-l-arginine)
and/or L-NAME (NG-nitro-l-arginine methyl ester) in cultured human corneal epithelial cells …
cationic amino acid transporters (hCATs, y+ transporter, the main transporter of l-arginine
and l-lysine) and human β-defensin (important components of immune function) production
on the ocular surface, arginase and nitrate monoxide synthase (NOS), enzymes that
compete for l-arginine, were inhibited by norNOHA (N (omega)-hydroxy-nor-l-arginine)
and/or L-NAME (NG-nitro-l-arginine methyl ester) in cultured human corneal epithelial cells …