Sensing of bacteria: NOD a lonely job

TA Kufer, PJ Sansonetti - Current opinion in microbiology, 2007 - Elsevier
TA Kufer, PJ Sansonetti
Current opinion in microbiology, 2007Elsevier
Recognition of bacteria by the vertebrate innate immune system relies on detection of
invariant molecules by specialized receptors. The view is emerging that activation of both
Toll-like receptors (TLRs) and Nod-like receptors (NLRs) by different bacterial agonists is
important in order to mount an inflammatory response in the host. Priming of cells with
peptidoglycan and products that are sensed by cytosolic-localized members of the NLR
family have a synergistic effect on TLR signalling and vice versa. Currently, the underlying …
Recognition of bacteria by the vertebrate innate immune system relies on detection of invariant molecules by specialized receptors. The view is emerging that activation of both Toll-like receptors (TLRs) and Nod-like receptors (NLRs) by different bacterial agonists is important in order to mount an inflammatory response in the host. Priming of cells with peptidoglycan and products that are sensed by cytosolic-localized members of the NLR family have a synergistic effect on TLR signalling and vice versa. Currently, the underlying molecular mechanisms of this cross-talk between NLR and TLR signalling are beginning to emerge. These reveal that the two sensing-systems are non-redundant in bacterial recognition and that their cross-talk plays an important role in immunological homeostasis.
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