[HTML][HTML] Pancreatic β cell-specific transcription of thepdx-1 gene: the role of conserved upstream control regions and their hepatic nuclear factor 3β sites
K Gerrish, M Gannon, D Shih, E Henderson… - Journal of Biological …, 2000 - ASBMB
To identify potential transactivators ofpdx-1, we sequenced approximately 4.5 kilobases of
the 5′ promoter region of the human and chicken homologs, assuming that sequences
conserved with the mouse gene would contain criticalcis-regulatory elements. The
sequences associated with hypersensitive site 1 (HSS1) represented the principal area of
homology within which three conserved subdomains were apparent: area I (− 2694 to− 2561
base pairs (bp)), area II (− 2139 to− 1958 bp), and area III (− 1879 to− 1799 bp). The …
the 5′ promoter region of the human and chicken homologs, assuming that sequences
conserved with the mouse gene would contain criticalcis-regulatory elements. The
sequences associated with hypersensitive site 1 (HSS1) represented the principal area of
homology within which three conserved subdomains were apparent: area I (− 2694 to− 2561
base pairs (bp)), area II (− 2139 to− 1958 bp), and area III (− 1879 to− 1799 bp). The …