[HTML][HTML] Expanding role of ubiquitination in NF-κB signaling
Best known for its role in targeting protein degradation by the proteasome, ubiquitin
modification has also emerged as an important mechanism that regulates cell signaling
through proteasome-independent mechanisms. The role of ubiquitin as a versatile signaling
tag is characteristically illustrated in the NF-κB pathways, which regulate a variety of
physiological and pathological processes in response to diverse stimuli. Here, we review the
role of ubiquitination in different steps of the NF-κB signaling cascades, focusing on recent …
modification has also emerged as an important mechanism that regulates cell signaling
through proteasome-independent mechanisms. The role of ubiquitin as a versatile signaling
tag is characteristically illustrated in the NF-κB pathways, which regulate a variety of
physiological and pathological processes in response to diverse stimuli. Here, we review the
role of ubiquitination in different steps of the NF-κB signaling cascades, focusing on recent …
Abstract
Best known for its role in targeting protein degradation by the proteasome, ubiquitin modification has also emerged as an important mechanism that regulates cell signaling through proteasome-independent mechanisms. The role of ubiquitin as a versatile signaling tag is characteristically illustrated in the NF-κB pathways, which regulate a variety of physiological and pathological processes in response to diverse stimuli. Here, we review the role of ubiquitination in different steps of the NF-κB signaling cascades, focusing on recent advances in understanding the mechanisms of protein kinase activation by polyubiquitin chains in different pathways that converge on NF-κB.
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