[HTML][HTML] MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic β-cell lines
MicroRNAs (miRNAs) are short non-coding RNAs that have been implicated in fine-tuning
gene regulation, although the precise roles of many are still unknown. Pancreatic
development is characterized by the complex sequential expression of a gamut of
transcription factors. We have performed miRNA expression profiling at two key stages of
mouse embryonic pancreas development, e14. 5 and e18. 5. miR-124a2 expression was
strikingly increased at e18. 5 compared with e14. 5, suggesting a possible role in …
gene regulation, although the precise roles of many are still unknown. Pancreatic
development is characterized by the complex sequential expression of a gamut of
transcription factors. We have performed miRNA expression profiling at two key stages of
mouse embryonic pancreas development, e14. 5 and e18. 5. miR-124a2 expression was
strikingly increased at e18. 5 compared with e14. 5, suggesting a possible role in …