The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease
DR Riddell, H Zhou, TA Comery, E Kouranova… - Molecular and Cellular …, 2007 - Elsevier
Recent studies show that intracellular cholesterol levels can modulate the processing of
amyloid precursor protein to Aβ peptide. Moreover, cholesterol-rich apoE-containing
lipoproteins may also promote Aβ clearance. Agonists of the liver X receptor (LXR)
transcriptionally induce genes involved in intracellular lipid efflux and transport, including
apoE. Thus, LXR agonists have the potential to both inhibit APP processing and promote Aβ
clearance. Here we show that LXR agonist, TO901317, increased hippocampal ABCA1 and …
amyloid precursor protein to Aβ peptide. Moreover, cholesterol-rich apoE-containing
lipoproteins may also promote Aβ clearance. Agonists of the liver X receptor (LXR)
transcriptionally induce genes involved in intracellular lipid efflux and transport, including
apoE. Thus, LXR agonists have the potential to both inhibit APP processing and promote Aβ
clearance. Here we show that LXR agonist, TO901317, increased hippocampal ABCA1 and …