Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD-scid IL2Rγnull Mice Engrafted with Human …
MB Jiménez-Díaz, T Mulet, S Viera… - Antimicrobial agents …, 2009 - Am Soc Microbiol
MB Jiménez-Díaz, T Mulet, S Viera, V Gómez, H Garuti, J Ibánez, A Alvarez-Doval, LD Shultz…
Antimicrobial agents and chemotherapy, 2009•Am Soc MicrobiolMurine models of Plasmodium falciparum malaria may become crucial tools in drug
discovery. Here we show that non-myelodepleted NOD-scid IL2Rγ null mice engrafted with
human erythrocytes support an infectious burden up to tenfold higher than that supported by
engrafted NOD-scid β2microglobulin null mice. The new model was validated for drug
discovery and was used to assess the therapeutic efficacy of 4-pyridones, selective
inhibitors of P. falciparum cytochrome bc 1.
discovery. Here we show that non-myelodepleted NOD-scid IL2Rγ null mice engrafted with
human erythrocytes support an infectious burden up to tenfold higher than that supported by
engrafted NOD-scid β2microglobulin null mice. The new model was validated for drug
discovery and was used to assess the therapeutic efficacy of 4-pyridones, selective
inhibitors of P. falciparum cytochrome bc 1.
Abstract
Murine models of Plasmodium falciparum malaria may become crucial tools in drug discovery. Here we show that non-myelodepleted NOD-scid IL2Rγnull mice engrafted with human erythrocytes support an infectious burden up to tenfold higher than that supported by engrafted NOD-scid β2microglobulinnull mice. The new model was validated for drug discovery and was used to assess the therapeutic efficacy of 4-pyridones, selective inhibitors of P. falciparum cytochrome bc1.
American Society for Microbiology