[HTML][HTML] SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein α transcriptional complex
L Qiao, J Shao - Journal of Biological Chemistry, 2006 - ASBMB
Adiponectin is an adipose-derived hormone that plays an important role in maintaining
energy homeostasis. Adiponectin gene expression is diminished in both obesity and type 2
diabetes. However, the mechanism underlying the impaired adiponectin gene expression
remains poorly understood. Recent studies have indicated that forkhead transcription factor
O1 (Foxo1) and silent information regulator 2 mammalian ortholog SIRT1 are involved in
adipogenesis. Here we have shown that Foxo1 up-regulates adiponectin gene transcription …
energy homeostasis. Adiponectin gene expression is diminished in both obesity and type 2
diabetes. However, the mechanism underlying the impaired adiponectin gene expression
remains poorly understood. Recent studies have indicated that forkhead transcription factor
O1 (Foxo1) and silent information regulator 2 mammalian ortholog SIRT1 are involved in
adipogenesis. Here we have shown that Foxo1 up-regulates adiponectin gene transcription …