klotho is an aging suppressor gene and extends life span when overexpressed in mice.
Klotho protein was recently demonstrated to function as a hormone that inhibits
insulin/insulin-like growth factor-1 (IGF-1) signaling. Here we show that Klotho protein
increases resistance to oxidative stress at the cellular and organismal level in mammals.
Klotho protein activates the FoxO forkhead transcription factors that are negatively regulated
by insulin/IGF-1 signaling, thereby inducing expression of manganese superoxide …