Identification of inhibitors of HSF1 functional activity by high-content target-based screening
Q Au, Y Zhang, JR Barber, SC Ng, B Zhang - SLAS Discovery, 2009 - Elsevier
Cancer cells are known to experience a high level of stress and may require constant repair
for survival and proliferation. Recent studies showed that inhibition of heat shock factor 1
(HSF1), the key regulator for the stress-activated transcription of heat shock protein (HSP),
can reduce the tumorigenic potential of cancer cells. Such a “nononcogene addiction”
phenomenon makes HSF1 an attractive cancer drug target. Here, the authors report an
image-based high-content screening (HCS) assay for HSF1 functional inhibitors. A heat …
for survival and proliferation. Recent studies showed that inhibition of heat shock factor 1
(HSF1), the key regulator for the stress-activated transcription of heat shock protein (HSP),
can reduce the tumorigenic potential of cancer cells. Such a “nononcogene addiction”
phenomenon makes HSF1 an attractive cancer drug target. Here, the authors report an
image-based high-content screening (HCS) assay for HSF1 functional inhibitors. A heat …