CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)
LF Allen, J Sebolt-Leopold, MB Meyer - Seminars in oncology, 2003 - Elsevier
Several key growth factors, cytokines, and proto-oncogenes transduce their growth-and
differentiation-promoting signals through the mitogen-activated protein kinase or
extracellular signal-regulated protein kinase (ERK) cascade. Overexpression or constitutive
activation of this pathway has been shown to play an important role in the pathogenesis and
progression of breast and other cancers, making the components of this signaling cascade
potentially important as therapeutic targets. CI-1040 (PD184352) is an orally active, highly …
differentiation-promoting signals through the mitogen-activated protein kinase or
extracellular signal-regulated protein kinase (ERK) cascade. Overexpression or constitutive
activation of this pathway has been shown to play an important role in the pathogenesis and
progression of breast and other cancers, making the components of this signaling cascade
potentially important as therapeutic targets. CI-1040 (PD184352) is an orally active, highly …