[HTML][HTML] Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor α (TNFα) production via increased mRNA half-life in alcoholic …
Activation of Kupffer cells (KCs) by gut-derived lipopolysaccharide (LPS) and Toll-Like
Receptors 4 (TLR4)-LPS-mediated increase in TNFα production has a central role in the
pathogenesis of alcoholic liver disease. Micro-RNA (miR)-125b, miR-146a, and miR-155
can regulate inflammatory responses to LPS. Here we evaluated the involvement of miRs in
alcohol-induced macrophage activation. Chronic alcohol treatment in vitro resulted in a time-
dependent increase in miR-155 but not miR-125b or miR-146a levels in RAW 264.7 …
Receptors 4 (TLR4)-LPS-mediated increase in TNFα production has a central role in the
pathogenesis of alcoholic liver disease. Micro-RNA (miR)-125b, miR-146a, and miR-155
can regulate inflammatory responses to LPS. Here we evaluated the involvement of miRs in
alcohol-induced macrophage activation. Chronic alcohol treatment in vitro resulted in a time-
dependent increase in miR-155 but not miR-125b or miR-146a levels in RAW 264.7 …