Chronic lymphocytic leukemia: the pathologist's view of lymph node microenvironment
M Ponzoni, C Doglioni, F Caligaris-Cappio - Seminars in diagnostic …, 2011 - Elsevier
Chronic lymphocytic leukemia (CLL), an indolent B-cell malignancy frequently diagnosed in
the elderly, is characterized by the relentless accumulation of CD5+ monoclonal B cells that
proliferate in the appropriate tissue microenvironments. Despite many advances achieved
by molecular and functional studies, our knowledge of the reciprocal relationship between
the CLL cell and its microenvironment at the tissue level is still largely incomplete. In this
review we present the relevant current information on the tissue microenvironmental …
the elderly, is characterized by the relentless accumulation of CD5+ monoclonal B cells that
proliferate in the appropriate tissue microenvironments. Despite many advances achieved
by molecular and functional studies, our knowledge of the reciprocal relationship between
the CLL cell and its microenvironment at the tissue level is still largely incomplete. In this
review we present the relevant current information on the tissue microenvironmental …