[HTML][HTML] A common human μ-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain
BG Oertel, M Kettner, K Scholich, C Renné… - Journal of Biological …, 2009 - ASBMB
The single nucleotide polymorphism 118A> G of the human μ-opioid receptor gene OPRM1,
which leads to an exchange of the amino acid asparagine (N) to aspartic acid (D) at position
40 of the extracellular receptor region, alters the in vivo effects of opioids to different degrees
in pain-processing brain regions. The most pronounced N40D effects were found in brain
regions involved in the sensory processing of pain intensity. Using the μ-opioid receptor-
specific agonist DAMGO, we analyzed the μ-opioid receptor signaling, expression, and …
which leads to an exchange of the amino acid asparagine (N) to aspartic acid (D) at position
40 of the extracellular receptor region, alters the in vivo effects of opioids to different degrees
in pain-processing brain regions. The most pronounced N40D effects were found in brain
regions involved in the sensory processing of pain intensity. Using the μ-opioid receptor-
specific agonist DAMGO, we analyzed the μ-opioid receptor signaling, expression, and …