Dopamine antagonist and'binge'cocaine effects on rat opioid and dopamine transporter mRNAs

R Spangler, Y Zhou, CE Maggos, A Zlobin, A Ho… - …, 1996 - journals.lww.com
The modulation by selective dopamine receptor antagonists of the effects of'binge'cocaine
(3±15 mg kg− 1 day− 1, ip, for 3 days after 11 days of adaptation to saline injections) on
preproenkephalin, preprodynorphin, K opioid receptor and dopamine transporter mRNAs
was determined. Adminstration of cocaine was preceded by daily single injections of a D1
(SCH 23390; 2 mg kg− 1) or the D2 (sulpiride; 50 mg kg− 1) dopamine receptor antagonist.
The D1, and not the D2, antagonist blocked cocaine-induced preprodynorphin and …