Chronic vulnerability to relapse is a formidable challenge for the treatment of drug addiction.
The neurobiological basis of relapse and its prevention has, therefore, attracted major
attention in addiction research. Current conceptualizations of addiction recognize craving as
a central driving force for ongoing drug use, as well as for relapse following abstinence.
Progress has been made in understanding experiential factors, neurocircuitry components
and signaling mechanisms that mediate conditioned drug-seeking behaviour, craving and …