Increased CRH mRNA levels in the rat amygdala during short-term withdrawal from chronic 'binge'cocaine
Y Zhou, R Spangler, A Ho, MJ Kreek - Molecular brain research, 2003 - Elsevier
There is evidence that suggests that increased corticotropin-releasing hormone (CRH)
release in the central nucleus of the amygdala underlies the anxiogenic and stress-like
consequences of withdrawal that are common in phenomenology to all drugs of abuse. The
present studies were undertaken to determine levels of CRH mRNA in the amygdala, and
also in the hypothalamus, frontal cortex and brainstem after short-term (2 days) and
intermediate-term (10 days) cocaine withdrawal (with continued saline injections) from …
release in the central nucleus of the amygdala underlies the anxiogenic and stress-like
consequences of withdrawal that are common in phenomenology to all drugs of abuse. The
present studies were undertaken to determine levels of CRH mRNA in the amygdala, and
also in the hypothalamus, frontal cortex and brainstem after short-term (2 days) and
intermediate-term (10 days) cocaine withdrawal (with continued saline injections) from …