Cocaine tolerance: behavioral, cardiovascular, and neuroendocrine function in men
JH Mendelson, M Sholar, NK Mello, SK Teoh… - …, 1998 - Elsevier
Cocaine tolerance was assessed by comparing the acute effects of cocaine in drug-
abstinent men who reported occasional cocaine use (n= 6) and in men who met DSM-III-R
diagnostic criteria for dependence on both cocaine and opiates (n= 6). Peak plasma cocaine
levels were equivalent in the two groups, and pharmacokinetic analyses revealed no
significant differences in cocaine levels at any time. Cocaine induced a significantly greater
increase in ACTH in the occasional cocaine users than in the cocaine dependent men (p< …
abstinent men who reported occasional cocaine use (n= 6) and in men who met DSM-III-R
diagnostic criteria for dependence on both cocaine and opiates (n= 6). Peak plasma cocaine
levels were equivalent in the two groups, and pharmacokinetic analyses revealed no
significant differences in cocaine levels at any time. Cocaine induced a significantly greater
increase in ACTH in the occasional cocaine users than in the cocaine dependent men (p< …