ACTH, cortisol and β-endorphin response to metyrapone testing during chronic methadone maintenance treatment in humans
MJ Kreek, J Ragunath, S Plevy, D Hamer, B Schneider… - Neuropeptides, 1984 - Elsevier
Normal responses to metyrapone were observed in most steady-state methadone
maintained treatment patients. These preliminary studies suggest that in recently detoxified
methadone maintained treatment patients, there may be an exaggerated response of the
hypothalamic-pituitary-adrenal axis to metyrapone.
maintained treatment patients. These preliminary studies suggest that in recently detoxified
methadone maintained treatment patients, there may be an exaggerated response of the
hypothalamic-pituitary-adrenal axis to metyrapone.