In studies of patients having maintenance treatment for heroin addiction (stabilized with
methadone hydrochloride in high doses of 80 to 120 mg daily), we found minimal side
effects and no toxic effects. These studies have included a prospective study of the first
consecutive 214 patients admitted to methadone treatment and reevaluation of the 129
patients of this group still in treatment after three or more years. In addition, we studied 1,435
methadone maintenance patients retrospectively and performed special studies on a …