Histological transformation of follicular lymphoma (FL) to a more aggressive non-Hodgkin's
lymphomas is a pivotal event in the natural history of FL and is associated with poor
outcome. While commonly observed in clinical practice and despite multiple studies
designed to address its pathogenesis, the biology of this process represents an enigma. In
this chapter we present a state of the art review summarizing the definition of histologic
transformation, its incidence, pathogenesis, clinical manifestations, treatment and outcome …