PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia
T Yamamoto, M Isomura, Y Xu, J Liang, H Yagasaki… - Leukemia research, 2006 - Elsevier
PTPN11, the gene which encodes protein tyrosine phosphatase SHP-2, plays an important
role in regulating intracellular signaling. Germline mutations in PTPN11 were first observed
in Noonan syndrome, while somatic mutations were identified in hematological myeloid
malignancies. Recently, PTPN11 mutations have been reported in children with acute
lymphoblastic leukemia (ALL). In the present study, we investigated the prevalence of
mutations in PTPN11, RAS and FLT3 in samples from 95 Japanese children with ALL. We …
role in regulating intracellular signaling. Germline mutations in PTPN11 were first observed
in Noonan syndrome, while somatic mutations were identified in hematological myeloid
malignancies. Recently, PTPN11 mutations have been reported in children with acute
lymphoblastic leukemia (ALL). In the present study, we investigated the prevalence of
mutations in PTPN11, RAS and FLT3 in samples from 95 Japanese children with ALL. We …