The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo
P Andreasson, J Schwaller, E Anastasiadou… - Cancer genetics and …, 2001 - Elsevier
ETV6/CBFA2 (TEL/AML1) is the most frequent genetic abnormality associated with acute
lymphoblastic leukemias in children, and is associated with a favorable prognosis. To
investigate the influence of ETV6/CBFA2 on cellular transformation, the fusion gene was
cloned into a murine ecotropic retroviral vector and transduced into IL-3–dependent Ba/F3
and 32Dcl. 3 and IL-7–dependent IxN/2b murine hematopoietic cell lines. Different variants
of ETV6/CBFA2, corresponding to CBFA2 alternatively spliced variants, and the reciprocal …
lymphoblastic leukemias in children, and is associated with a favorable prognosis. To
investigate the influence of ETV6/CBFA2 on cellular transformation, the fusion gene was
cloned into a murine ecotropic retroviral vector and transduced into IL-3–dependent Ba/F3
and 32Dcl. 3 and IL-7–dependent IxN/2b murine hematopoietic cell lines. Different variants
of ETV6/CBFA2, corresponding to CBFA2 alternatively spliced variants, and the reciprocal …