Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
I Lahortiga, K De Keersmaecker, P Van Vlierberghe… - Nature …, 2007 - nature.com
I Lahortiga, K De Keersmaecker, P Van Vlierberghe, C Graux, B Cauwelier, F Lambert…
Nature genetics, 2007•nature.comWe identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute
lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated
with a threefold increase in MYB expression, and knockdown of MYB expression initiates T
cell differentiation. Our results identify duplication of MYB as an oncogenic event and
suggest that MYB could be a therapeutic target in human T-ALL.
lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated
with a threefold increase in MYB expression, and knockdown of MYB expression initiates T
cell differentiation. Our results identify duplication of MYB as an oncogenic event and
suggest that MYB could be a therapeutic target in human T-ALL.
Abstract
We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.
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