Pharmacokinetics of nicotinamide in cancer patients treated with accelerated radiotherapy: the experience of the Co-operative Group of Radiotherapy of the European …
J Bernier, MRL Stratford, J Denekamp… - Radiotherapy and …, 1998 - Elsevier
Background: The EORTC has initiated studies to combine nicotinamide with carbogen in
accelerated fractionation schedules (ARCON), since for some tumour types, acute and
chronic hypoxia as well as treatment protraction may prejudice the outcome of radiotherapy.
The tolerable dose of nicotinamide and the optimal interval for administration need to be
ascertained. Aim: Full pharmacokinetic profiles of nicotinamide concentrations in plasma
were analyzed repeatedly in 15 patients to determine the inter-and intra-patient variability in …
accelerated fractionation schedules (ARCON), since for some tumour types, acute and
chronic hypoxia as well as treatment protraction may prejudice the outcome of radiotherapy.
The tolerable dose of nicotinamide and the optimal interval for administration need to be
ascertained. Aim: Full pharmacokinetic profiles of nicotinamide concentrations in plasma
were analyzed repeatedly in 15 patients to determine the inter-and intra-patient variability in …