[HTML][HTML] Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model
K Hashimoto, RN Cohen, M Yamada… - Journal of Biological …, 2006 - ASBMB
Hypercholesterolemia is found in patients with hypothyroidism and resistance to thyroid
hormone. In this study, we examined cholesterol metabolism in a thyroid hormone receptor β
(TR-β) mutant mouse model of resistance to thyroid hormone. Whereas studies of
cholesterol metabolism have been reported in TR-β knock-out mice, generalized expression
of a non-ligand binding TR-β protein in this knock-in model more fully recapitulates the
hypothyroid state, because the hypothyroid effect of TRs is mediated by the unliganded …
hormone. In this study, we examined cholesterol metabolism in a thyroid hormone receptor β
(TR-β) mutant mouse model of resistance to thyroid hormone. Whereas studies of
cholesterol metabolism have been reported in TR-β knock-out mice, generalized expression
of a non-ligand binding TR-β protein in this knock-in model more fully recapitulates the
hypothyroid state, because the hypothyroid effect of TRs is mediated by the unliganded …