The MPTP model of Parkinson's disease
RJ Smeyne, V Jackson-Lewis - Molecular brain research, 2005 - Elsevier
The biochemical and cellular changes that occur following administration of 1-methyl-4-
phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) are remarkably similar to that seen in idiopathic
Parkinson's disease (PD). In this review, we detail the molecular activities of this compound
from peripheral intoxication through its various biotransformations. In addition, we detail the
interplay that occurs between the different cellular compartments (neurons and glia) that
eventually consort to kill substantia nigra pars compacta (SNpc) neurons.
phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) are remarkably similar to that seen in idiopathic
Parkinson's disease (PD). In this review, we detail the molecular activities of this compound
from peripheral intoxication through its various biotransformations. In addition, we detail the
interplay that occurs between the different cellular compartments (neurons and glia) that
eventually consort to kill substantia nigra pars compacta (SNpc) neurons.