[HTML][HTML] CCAAT enhancer-binding protein α is required for interleukin-6 receptor α signaling in newborn hepatocytes
SL Mackey, GJ Darlington - Journal of Biological Chemistry, 2004 - ASBMB
The acute phase response is an evolutionarily conserved response of the liver to
inflammatory stimuli, which aids the body in host defense and homeostasis. We have
previously reported that CCAAT enhancer-binding protein α (C/EBPα) is required for the
induction of acute phase protein (APP) genes in newborn mice in response to
lipopolysaccharide. In this paper, we describe a mechanism by which C/EBPα knock-out
mice are unable to induce APP gene expression in response to inflammatory stimuli. We …
inflammatory stimuli, which aids the body in host defense and homeostasis. We have
previously reported that CCAAT enhancer-binding protein α (C/EBPα) is required for the
induction of acute phase protein (APP) genes in newborn mice in response to
lipopolysaccharide. In this paper, we describe a mechanism by which C/EBPα knock-out
mice are unable to induce APP gene expression in response to inflammatory stimuli. We …