[HTML][HTML] Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8
X Fan, AC Patera, A Pong-Kennedy, G Deno… - Journal of Biological …, 2007 - ASBMB
Functional interleuin-8 (IL-8) receptors (IL-8RA and IL-8RB: CXCR1 and CXCR2,
respectively) have been described in human, monkey, dog, rabbit, and guinea pig. Although
three IL-8R homologues have been found in rat, only one of these, rat CXCR2, appears to
be functional based on responsiveness to ligands. Similarly, CXC chemokines induce
biological responses through the murine homolog of CXCR2, but the identification of
functional rodent CXCR1 homologues has remained elusive. We have identified and …
respectively) have been described in human, monkey, dog, rabbit, and guinea pig. Although
three IL-8R homologues have been found in rat, only one of these, rat CXCR2, appears to
be functional based on responsiveness to ligands. Similarly, CXC chemokines induce
biological responses through the murine homolog of CXCR2, but the identification of
functional rodent CXCR1 homologues has remained elusive. We have identified and …