[HTML][HTML] Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell …
RJ DeBerardinis, JJ Lum, CB Thompson - Journal of Biological Chemistry, 2006 - ASBMB
An abundant supply of extracellular nutrients is believed to be sufficient to suppress
catabolism of cellular macromolecules. Here we show that, despite abundant extracellular
nutrients, interleukin-3-deprived hematopoietic cells begin to catabolize intracellular lipids.
Constitutive Akt activation blunts the increased β-oxidation that accompanies growth factor
withdrawal, and in growth factor-replete cells, phosphatidylinositol 3-kinase (PI3K) signaling
is required to suppress lipid catabolism. Surprisingly, PI3K and Akt exert these effects by …
catabolism of cellular macromolecules. Here we show that, despite abundant extracellular
nutrients, interleukin-3-deprived hematopoietic cells begin to catabolize intracellular lipids.
Constitutive Akt activation blunts the increased β-oxidation that accompanies growth factor
withdrawal, and in growth factor-replete cells, phosphatidylinositol 3-kinase (PI3K) signaling
is required to suppress lipid catabolism. Surprisingly, PI3K and Akt exert these effects by …