Breast cancer molecular subtypes in patients with locally advanced disease: impact on prognosis, patterns of recurrence, and response to therapy
KE Huber, LA Carey, DE Wazer - Seminars in radiation oncology, 2009 - Elsevier
Gene expression profiling has led to the discovery of 4 distinct molecular subtypes of breast
cancer: luminal A, luminal B, basal like, and HER2 enriched. Investigation of these subtypes
in women with breast cancer has given insight into the heterogeneous biology and
outcomes in patients with locally advanced disease. These subtypes have been found to be
predictors for survival, response to systemic therapy, and locoregional recurrence. This
review discusses the biology of locally advanced breast cancer and the available data on …
cancer: luminal A, luminal B, basal like, and HER2 enriched. Investigation of these subtypes
in women with breast cancer has given insight into the heterogeneous biology and
outcomes in patients with locally advanced disease. These subtypes have been found to be
predictors for survival, response to systemic therapy, and locoregional recurrence. This
review discusses the biology of locally advanced breast cancer and the available data on …